Protein Modification Reagents
eMolecules m-PEG17-propargyl | Broadpharm | 146185-77-5 | MFCD27977517 | 774.939 | C36H70O17 | 95.000 | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCC#C | 250mg | 229582219
m-PEG17-propargyl | Broadpharm | 146185-77-5 | MFCD27977517 | 774.939 | C36H70O17 | 95.000 | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCC#C | 250mg | 229582219
Medchemexpress LLC Boc-NH-PEG4-C2-Boc | 2138484-13-4 | 421.53 | 25 MG
Boc-NH-PEG4-C2-Boc is a PEG-based PROTAC linker used in the synthesis of Proteolysis Targeting Chimeras (PROTACs). These molecules are designed to selectively degrade target proteins by exploiting the intracellular ubiquitin-proteasome system. PROTACs feature two different ligands connected by a linker, where one ligand targets an E3 ubiquitin ligase and the other targets a specific protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs contain two ligands connected by a linker
- Targets an E3 ubiquitin ligase
- Targets a specific protein
- Exploits the intracellular ubiquitin-proteasome system for selective protein degradation
Medchemexpress LLC m-PEG4-CH2COOH | 16024-66-1 | 99.9% | 1 G
This PEG-based PROTAC linker is used in the synthesis of PROTACs. It is intended for research applications.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Purity of 99.86%
- Molecular formula C11H22O7
- Molecular weight 266.29
- Appears as a colorless to light yellow liquid
- Specific storage conditions for pure form and in solvent
- Soluble in various solvents for in vitro and in vivo studies
- Relevant for cancer and cancer targeted therapy research
Medchemexpress LLC DBCO-PEG4-eosin 5-isothiocyanate | 96.7% | 1228.59 | C50H44Br4N4O11S | 10 MG
DBCO-PEG4-Eosin 5-isothiocyanate is a click-chemistry-enabled fluorescent probe that links a DBCO (dibenzocyclooctyne) reactive group to eosin 5-isothiocyanate via a PEG4 spacer. It is supplied as an orange-red solid for labeling biomolecules using strain-promoted alkyne-azide cycloaddition (SPAAC) and for fluorescence imaging applications.
- Enables copper-free click conjugation via DBCO
- PEG4 spacer improves solubility and reduces steric hindrance
- Eosin 5-isothiocyanate offers red-orange fluorescence for imaging
- High purity suitable for bioconjugation applications
- Supplied in small milligram quantities for research use
- Store sealed, protected from moisture and light; refrigerate for solids
Medchemexpress LLC Propargyl-PEG4-5-nitrophenyl carbonate | 1422540-81-5 | 98.2% | 397.38 | 50 MG
Propargyl-PEG4-5-nitrophenyl carbonate is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It also functions as a click chemistry reagent, featuring an Alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent
- Features an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
- Exploits ubiquitin-proteasome system for selective protein degradation
Medchemexpress LLC 1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine-N-azide | 2839508-98-2 | 96.4% | 831.11 g/mol | C43H83N4O9P | 5 MG
DSPE-N3 is an azide-functionalized distearoyl phosphoethanolamine used as a click-chemistry lipid for bioconjugation and nanoparticle formulation. The amphiphilic molecule presents an azide headgroup that enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) to attach alkyne-containing probes, polymers, or targeting ligands, and is commonly applied in liposome and micelle formation, surface functionalization, and targeted delivery research.
- Contains an azide functional group for bioorthogonal click chemistry
- Amphiphilic structure supports liposome and micelle formation
- Suitable for conjugation of alkyne-bearing molecules via CuAAC
- High chemical purity for research-grade applications
- Store sealed at 4°C and protect from moisture for stability
- Available in small lab-scale quantities for formulation work
Medchemexpress LLC Dspe-biotin | 133695-76-8 | 97.5% | 974.36 g/mol | C51H96N3O10PS | 5 MG
DSPE-Biotin is a biotinylated phospholipid designed to introduce biotin functional groups into liposomes, supported lipid bilayers, and other lipid-based systems for labeling, affinity capture, and biochemical assays. It is provided at high purity for research applications and should be handled and stored according to the supplier's recommendations.
- Biotinylated lipid for affinity capture and labeling.
- Compatible with liposome and supported bilayer formulations.
- High purity for reproducible experimental results.
- Soluble in DMSO (≈1.3 mg/mL) with ultrasonic warming to aid dissolution.
- Recommended long-term storage at -20°C protected from light.
- Useful for biochemical assays, surface functionalization, and probe attachment.
Cayman Chemical dPE-PEG 2000-DBCO 10mg
An internal standard for the quantification of betahistine by GC- or LC-MS
Medchemexpress LLC Cl-PEG4-acid 50mg
Cl-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]
Medchemexpress LLC Azido-PEG4-azide | 182760-73-2 | ≥97.0% | 288.30 | 250 MG
Azido-PEG4-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This click chemistry reagent features an Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It also undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
- PEG-based PROTAC linker
- Used for PROTAC synthesis
- Click chemistry reagent
- Contains an Azide group
- Participates in CuAAc reactions with alkyne groups
- Undergoes SPAAC reactions with DBCO or BCN groups
Broadpharm Mal-PEG8-NHS ester | 2055033-05-9 | MFCD26127784 | 100mg
Mal-PEG8-NHS ester | Putity: 97% | MW: 618.6 | 2055033-05-9 | MFCD26127784 | 100mg
Medchemexpress LLC 4,7,10,13-tetraoxapentadecanoic acid, 15-hydroxy-, 1,1-dimethylethyl ester | 518044-32-1 | 99.3% | 322.39 g/mol | C15H30O7 | 25 G
Hydroxy-PEG4-(CH2)2-Boc is a hydroxy-terminated PEG4 spacer with a Boc-protected terminal group used as a linker in bioconjugation chemistry. It is commonly employed for antibody-drug conjugate and PROTAC synthesis, and is provided at high purity for research use only.
- Hydroxy-terminated PEG4 spacer with Boc-protected terminal
- Uncleavable linker suitable for antibody-drug conjugate synthesis
- Applicable as a PROTAC linker in targeted protein degradation workflows
- High purity (99.3% by GC) with characterized molecular weight 322.39 g/mol
- Available in multiple pack sizes, including 25 g
- For research use only; not validated for medical applications
Medchemexpress LLC Mal-amido-PEG2-Val-Cit-PAB-PNP | 2112738-13-1 | 98.4% | 854.86 g/mol | C39H50N8O14 | 50 MG
Mal-amido-PEG2-Val-Cit-PAB-PNP is a cleavable two-unit PEG linker designed for use in the synthesis of antibody-drug conjugates (ADCs). It contains a val-cit dipeptide cleavable moiety, a p-aminobenzyl (PAB) self-immolative spacer, a para-nitrophenyl (PNP) leaving group, and a maleimide-amido PEG2 spacer for thiol conjugation.
- Cleavable val-cit dipeptide for enzyme-triggered payload release.
- PAB self-immolative spacer enables efficient drug release after cleavage.
- Maleimide-amido PEG2 spacer for thiol-selective conjugation to antibodies.
- High reported purity suitable for research-grade ADC synthesis.
- Available in small research sizes for development and testing.
Medchemexpress LLC Mal-PEG2-VCP-eribulin | 2130869-18-8 | MFCD32068377 | 99.8% | 1374.57 | C70H99N7O21 | 10 MG
Mal-PEG2-VCP-eribulin is a drug-linker conjugate composed of an ADC linker (Mal-PEG2-VCP) covalently attached to eribulin. It is supplied as a solid for research use in the development of antibody-drug conjugates and related preclinical studies.
- Consists of an ADC linker conjugated to eribulin.
- CAS number 2130869-18-8.
- Molecular weight 1374.57.
- Chemical formula C70H99N7O21.
- Purity 99.8%.
- Supplied as a 10 MG solid; other pack sizes available on request.
- Store at -20°C, protect from light, under inert atmosphere; in solvent store at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Cyanine5 alkyne | 1223357-57-0 | 98.2% | C35H42ClN3O | 10MG
Cyanine5 alkyne is a near-infrared fluorescent dye bearing a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition (click chemistry). It enables covalent labeling of azide-functionalized biomolecules for fluorescence imaging and detection in biochemical assays.
- Click-reactive terminal alkyne enables CuAAC conjugation.
- Near-infrared excitation and emission for reduced background in imaging.
- High purity suitable for sensitive fluorescence assays.
- Available in multiple milligram sizes for flexible experimental use.
- Stable when stored sealed away from moisture and light.